Selective rescue of early haematopoietic progenitors in Scl–/– mice by expressing Scl under the control of a stem cell enhancer
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چکیده
منابع مشابه
Selective rescue of early haematopoietic progenitors in Scl(-/-) mice by expressing Scl under the control of a stem cell enhancer.
The stem cell leukaemia gene (Scl) encodes a basic helix-loop-helix transcription factor with a pivotal role in both haematopoiesis and endothelial development. During mouse development, Scl is first expressed in extra-embryonic mesoderm, and is required for the generation of all haematopoietic lineages and normal yolk sac angiogenesis. Ectopic expression of Scl during zebrafish development spe...
متن کاملAn SCL 3' enhancer targets developing endothelium together with embryonic and adult haematopoietic progenitors.
The SCL gene encodes a basic helix-loop-helix transcription factor which is expressed in early haematopoietic progenitors throughout ontogeny and is essential for the normal development of blood and blood vessels. Transgenic studies have characterised spatially distinct 5' enhancers which direct lacZ expression to subdomains of the normal SCL expression pattern, but the same elements failed to ...
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The mechanisms underlying maintenance of hematopoietic stem cells (HSCs) remain one of the critical mysteries in blood development. Because of advances in whole genome analysis and in reverse genetic animal model systems, there has been accelerating progress in identification of the genes involved in stem cell selfrenewal, lineage commitment and differentiation, and cell-cycle regulation. Criti...
متن کاملRescue of the lethal scl(-/-) phenotype by the human SCL locus.
The stem cell leukemia (SCL) gene encodes a basic helix-loop-helix transcription factor with a critical role in the development of both blood and endothelium. Loss-of-function studies have shown that SCL is essential for the formation of hematopoietic stem cells, for subsequent erythroid development and for yolk sac angiogenesis. SCL exhibits a highly conserved pattern of expression from mammal...
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ژورنال
عنوان ژورنال: Development
سال: 2001
ISSN: 1477-9129,0950-1991
DOI: 10.1242/dev.128.23.4815